A Phase 1b-2 Trial to Assess Venetoclax and Navitoclax Consolidation and Post-transplant Maintenance in High-risk Patients With T-ALL

Inclusion Criteria: 1. Age ≥ 18 years at the time of signing the informed consent document. 2. Have a documented new diagnosis of T-ALL, T-LBL or MPAL T/Myeloid according to the WHO 2016 classification. 3. Patients in first complete response that are planned for an alloSCT. 4. Patient induction with a BFM backbone, asparginase containing induction. 5. Adequate bone marrow reserve; • Absence of growth factors, thrombopoietic factors, or platelet transfusions in the week prior to day 1 of therapy with Navitoclax and venetoclax. * Platelet count ≥ 50 × 109 /L * Absolute neutrophil count (ANC) ≥ 1 × 109 /L. 6. Hepatic function and enzymes: * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3.0 × upper limit of normal (ULN) * Total bilirubin ≤ 1.5 × ULN (exception: subjects with Gilbert's Syndrome may have total bilirubin \> 1.5 × ULN) * Coagulation: activated partial thromboplastin time (aPTT) and international normalized ratio (INR) ≤ 1.5 × ULN. 7. Renal function: calculated creatinine clearance ≥ 30 mL/min • For the post-transplant maintenance phase:Patient should satisfy all the above criteria. • Patient must not have grade 2 or higher for aGvHD and moderate or severe for cGvHD. 9\. Females of childbearing potential (FCBP) may participate, providing they meet the following conditions: Agree to use at least two effective contraceptive methods (oral, injectable, or implantable hormonal contraceptive; tubal ligation; intra-uterine device; barrier contraceptive with spermicide; or vasectomized partner) throughout the study, and for 3 months following EOT; and have a negative serum or urine pregnancy test (investigator's discretion; sensitivity at least 25 mIU/mL) at screening; and have a negative serum or urine pregnancy test (investigator's discretion) within 72 hours prior to starting study therapy in the treatment phase (note that the screening serum pregnancy test can be used as the test prior to starting study therapy in treatment phase if it is performed within the 72-hour timeframe). 10\. Male subjects with a female partner of childbearing potential must agree to the use of at least two physician-approved contraceptive methods throughout the course of the study and should avoid fathering a child during the course of the study and for 3 months following the last dose of study drug. 11\. Understand and voluntarily sign an informed consent document prior to any study related assessments/procedures being conducted. 12\. Able to adhere to the study visit schedule and other protocol requirements. Exclusion Criteria: 1. Age \<18 at the time of signing the informed consent document. 2. Ph-positive disease. 3. Patient not regarded as candidates for allogeneic transplantation. 4. Non-BFM based, asparginase containing induction (including HyperCVAD) 5. Concomitant Medications: * Subject must not have been treated with a medical product without any global regulatory approvals within 30 days or 5 half-lives of the drug (whichever is shorter) prior to Cycle 1 Day 1 and must not be currently receiving AML treatment in another clinical interventional study. * Cytochrome P450 (CYP)3A inducers and grapefruit/grapefruit products: Subject must not have received a known strong or moderate CYP3A inducer 7 days prior to Cycle 1 Day 1. Subject must not have known medical conditions requiring chronic therapy of moderate CYP3A inducers. * Cytochrome P450 (CYP)3A inhibitors: Subject must not have received a known strong or moderate CYP3A inhibitors 7 days prior to Cycle 1 Day 1. Subject must not have known medical conditions requiring chronic therapy of strong or moderate CYP3A inhibitors (appendix 2). * Subject must not have consumed grapefruit, grapefruit products, Seville oranges (including marmalade containing Seville oranges), or starfruit within 3 days prior to Cycle 1 Day 1. * Subject must not have received any live vaccine within 4 weeks prior to Cycle 1 Day 1. * The subject must not be expected to need a live vaccination throughout study participation. * The subject must not be expected to need a live vaccine in case of the following 7 conditions: 1\. Less than 24 months following transplantation 2. Active GvHD 3. Lymphocyte count \< 1,500/μL 4. Less than 12 months in remission 5. Less than 3 months after the last dose of oncological therapy 6. Less than 4 weeks after the most recent infusion of immunoglobulins 7. Less than 4 weeks after the most recent immunosuppressive therapy • Subject must not have been treated with any investigational drug within 30 days prior to the first dose of study drug or is currently enrolled in another clinical study or was previously enrolled in this study 6\. Known Human Immunodeficiency Virus (HIV). 7\. No history of being positive for hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Inactive hepatitis carrier status or low viral hepatitis titers on antivirals (non-exclusionary medications) are not excluded. 8\. Known or suspected hypersensitivity to any of the study drugs. 9\. Pregnant or lactating females. 10\. Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. 11\. Any condition including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study. 12\. Participation to an investigational drug trial in the last month before randomization.