Conventional and Metabolomic Predictors of Prediabetes & Insulin Resistance

University of Michigan772 enrolled

Overview

The purpose of this study is to evaluate the longitudinal test performance of an array of conventional biomarkers of glycemia, including Hemoglobin A1c (HbA1c), and novel metabolomic biomarkers for identifying progression of glucose tolerance (normal to prediabetes or prediabetes to diabetes) in an overweight and obese pediatric cohort.

Study Type

OBSERVATIONAL

Enrollment

772

Conditions

PreDiabetes Obesity, Childhood

Eligibility

Sex: ALLMin age: 8 YearsMax age: 22 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Groups 1 and 2 (overweight and obese groups): * Age 8-17 years for the visits #1 and #2, individuals can be as old as 22 years for follow-up visits #3 and 4 * Overweight or obese, as defined by a BMI ≥ 85th% \& \<95th% or BMI ≥ 95th%, respectively by age and sex, and for those 16 years and older, BMI ≥25 and \<30 and BMI ≥30 * For Group 2 only: previously completed visits 1-2 in 2007-2013 and formally agreed to be re-contacted for study purposes * Group 3 (Normal weight controls): * Age 8-17 years * Healthy weight, as defined by a BMI ≥ 5th percentile \& \< 85th percentile, respectively by age and sex Exclusion Criteria: * Previous diagnosis of type 1 diabetes * Use of concurrent medications known to affect glucose metabolism (metformin, oral steroids, sulfonylureas, insulin) * Verbal report of Pregnancy

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

Progression of glucose tolerance

Normal glucose tolerance, prediabetes, or diabetes

Time frame: Up to 5 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.