With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring through assisted reproductive technology. However, a growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. The purpose of this study is to investigate the stress faced by participants undergoing ART with different cycles and to further investigate its impact on pregnancy outcomes.
With the rapid social and economic development in recent years, the incidence of infertility has increased significantly due to environmental pollution, poor lifestyle habits and increasing stress in various areas. According to global statistics, one in six married couples suffers from infertility. With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring. In clinical practice, however, a significant proportion of patients undergoing ART have low embryo implantation and pregnancy rates and experience recurrent implantation failure (RIF). A growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. This effect is more pronounced in patients with multiple failed transfers. In this study, investigators intend to investigate the stress faced by participants undergoing assisted reproduction with different cycles to provide a reliable basis for future psychological interventions and health education for this group of patients and improve the quality of life of infertility patients.
Study Type
OBSERVATIONAL
Enrollment
200
Patients are grouped according to the number of IVF/ICSI cycles.
Women's Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
Implantation rate
Implantation rate is defined as number of sacs per embryo transferred.
Time frame: 6 months
clinical pregnancy rate
presence of at least one gestational sac on ultrasound of 6 weeks
Time frame: 6 months
fertilization rate
No. of fertilized oocyte divided by No. of inseminated cumulus-oocyte complexes (COCs)
Time frame: 6 months
cleavage rate
No. of cleaved embryo divided by No. of fertilized oocyte
Time frame: 6 months
Total gonadotropin use
Total gonadotropin use of each participant
Time frame: 6 months
Ovarian hyperstimulation syndrome (OHSS) rates
OHSS rates in both study groups
Time frame: 6 months
Number of oocytes retrieved
Time frame: 6 months
Metaphase II (MII) oocytes
the number of mature oocytes
Time frame: 6 months
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