Acute type A aortic dissection is often accompanied by postoperative hypoxemia, the cause of which is not fully understood. Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative hypoxemia after acute type A aortic dissection, and to provide reference for clinical application
Study Type
OBSERVATIONAL
Enrollment
88
No intervention
Anzhen hospital, Beijing
Beijing, Beijing Municipality, China
The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia.
Blood samples were taken within 24 hours after operation to detect the contents of ANG II in serum. Postoperative hypoxemia is defined by the oxygenation index (OI), which is the ratio of arterial partial pressure of oxygen to fraction inspired oxygen (PaO2 / FiO2), of less than or equal to 200 for two consecutive times within the first 24 h after operation
Time frame: Within 24 hours after surgery
The Risk Factors for Postoperative Hypoxemia in Stanford Type A Acute Aortic Dissection Patients.
Basic characteristics, intraoperative details, biochemical parameters and outcome results were obtained, and blood was collected within 24 hours after surgery for the measurement of ANG II, sACE2 and mir-145 concentrations. Univariate analysis was first performed to identify the potential risk factors for postoperative hypoxemia. Multivariate logistic regression analysis was performed for factors with P \< 0.05 or that were considered clinically important.
Time frame: up to 60 days
Duration of Stay in the Intensive Care Unit
Duration of Stay in the intensive care unit after surgery
Time frame: up to 60 days
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