Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:

Gulhane Training and Research Hospital450 enrolled

Overview

Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects. However, limited data are available concerning their contribution to time of onset of delirium. This study aimed to determine the potential association of higher anticholinergic burden to early-onset of delirium superimposed dementia in the older adult.

Study Type

OBSERVATIONAL

Enrollment

450

Conditions

Delirium Anticholinergic Adverse Reaction Alzheimer Disease

Interventions

Anticholinergic burdenDRUG

The anticholinergic burden (ACB) was assessed using the Anticholinergic Burden Scale. Higher ACB was described as equal or higher than 1.

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 65 years and older and diagnosis or fellow-up of Alzhemier dementia in outpatient clinic. Exclusion Criteria: * The patients with a history of other than Alzhemier dementia or neurodegenerative disease (epilepsy, multiple sclerosis, Parkinson disease, etc.), terminal illness (malignancy, advanced organ failure) were excluded.

Locations (1)

Gulhane training and research hospital

Ankara, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

Time onset of delirium superimposed dementia

First attack of delirium onset

Time frame: 12 month

Data from ClinicalTrials.gov

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