Normothermic Intraperitoneal Chemotherapy - Long Term in Peritoneal Metastases From Colorectal Cancer (NIPEC-OXA)

Inclusion Criteria: * Age 18 - 75 years * Able to provide written, informed consent regarding expected cooperation during treatment and follow-up according to ICH GCP, and national/local regulations * Histologically verified CRC * Histologically verified and/or radiologically/clinically suspected PM from CRC * Synchronous or metachronous PM from CRS * If neoadjuvant oxaliplatin-containing chemotherapy is administrated, patients with absence of progressive disease (assessed by CT) * In metachronous cases: if adjuvant oxaliplatin-containing chemotherapy, the interval between oxaliplatin- containing adjuvant chemotherapy and diagnosis of PM must be \>6 months * Intraperitoneal tumour burden amenable to CRC and HIPEC with Peritoneal Cancer Index (PCI40) ≤ 20, assessed at the time of surgery * Absence of other metastatic sites, i.e. liver, lungs, central lymph nodes * Completeness of Cytoreduction (CC) score of 0 is required * Eastern Cooperative Oncology Group (ECOG) Performance Status either 0 or 141 * Women of childbearing potential (WOCBP), defined as all women physiologically capable of becoming pregnant, should have a negative urine- or serum pregnancy test within 72 hours prior to receiving the 1st dose of study medication. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required. * WOCBP should be willing to use 1 highly effective method of birth control or be surgically sterile, or abstain from heterosexual activity for the course of the study through 120 days after the last dose of study medication. * Men in a sexual relationship with a WOCBP must agree to use a condom starting with the 1st dose of study therapy through 120 days after the last dose of study therapy. In case of female partner of child-bearing potential, the female partner should use 1 highly effective contraception method as defined in section 5.1.5 - "Other considerations". Exclusion Criteria: * Has a history of hypersensitivity to oxaliplatin or to any of the excipients listed in the SmPC section 6.1 * Has myelosuppression before starting treatment, ie number of neutrophils granulocytes \<1.0 x 109/l and/or number of platelets \<75 x 109/l * Has peripheral sensitive neuropathy with functional outcomes before starting treatment * Has severe renal impairment (creatinine clearance \< 30 ml min) (see the SmPC section 5.2). * Concurrent or previous diagnosis of invasive cancer within 5 years * Psychiatric or addictive disorder or other medical condition that would preclude the patient from meeting the trial requirements * Participation in another cancer clinical trial * Patients who, according to current guidelines will be offered i.v. adjuvant therapy * Significant cardiac or other medical illness that would limit activity or survival, such as severe congestive heart failure, unstable angina, or serious cardiac arrhythmia * Alcohol or drug abuse * Any reason why, in the opinion of the investigator, the patient should not participate * Has a known history of Human Immunodeficiency Virus (HIV) * Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA \[qualitative\] is detected) * Is pregnant or breastfeeding, or expecting to conceive or father children within the project duration of the trial, starting with the screening visit through 120 days after the last dose of trial treatment.