Omics Sequencing of Exosomes in Body Fluids of Patients With Acute Lung Injury

Inclusion Criteria: Inclusion criteria of experimental group: * Signed informed consent voluntarily; * Age: \>18 years old, gender: no restrictions ; * Patients with known clinical manifestations of respiratory impairment or new/aggravated respiratory symptoms diagnosed within one week of onset according to the Berlin definition guidelines. Control group inclusion criteria: * Age ≥18 years old (including 18 years old), male and female; * Male weight ≥50 kg, female weight ≥45kg, and body mass index (BMI) between 19 and 26(inclusive), BMI= weight (kg)/ height (㎡); * No smoking, alcohol addiction, no history of drug abuse; * No diabetes, asthma, copd, chronic renal insufficiency and other basic diseases; No history of major diseases or infectious diseases (including hepatitis B, hepatitis C, HIV, syphilis); * Those who have not taken drugs recently. Exclusion Criteria: Exclusion criteria of experimental group: * Patients with diabetes, chronic renal insufficiency, malignant tumors and other basic diseases; * severe malnutrition; * Pregnant or lactating women; * The researcher judged that he was not suitable to participate in this study. Exclusion criteria for the control group: * pregnant or lactation women; * severe malnutrition; * The researcher judged that he was not suitable to participate in this study.