A One Health Study of Monkeypox Human Infection

Institut Pasteur280 enrolled

Overview

This multidisciplinary project aim to understand the epidemiology of the monkeypox in Central African Republic through the identification of the animal reservoir, the clinical and epidemiological description of the human outbreak, through an ethnological approach around risk factors of the disease and through an ecological approach of the ecological context of emergence, and the improvement of biological diagnosis.

This project is composed by monkyepox disease outbreak investigation in the CAR following national surveillance framework.

Study Type

OBSERVATIONAL

Enrollment

280

Conditions

Monkeypox Virus Infection

Interventions

blood samplesOTHER

5 mL

Scabs and pus samplesOTHER

if available

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Human population in villages affected by monkeypox epidemics: patients who developed monkeypox and their contacts * Health care personnel (paramedics, nurses, doctors) who work or have worked in affected villages * Traditional healers, diviners * Members of villages affected by past monkeypox epidemics Exclusion Criteria: * area not accessible to investigation * refusal to participate * inability to obtain consent

Locations (1)

Institut Pasteur Bangui

Bangui, Central African Republic

Outcomes

Primary Outcomes

Proportion of monkeypox cases occuring following interhuman exposures

through a quantitative case-control study with an odds ratio of \>3 for an exposure factor for human-to-human transmission.

Time frame: 36 months

Proportion of monkeypox cases occuring following zoonotic exposures

through a quantitative case-control study with an odds ratio of \>3 for an exposure factor for zoonotic transmission.

Time frame: 36 months

Secondary Outcomes

Measurement of the Effective reproduction rate R in CAR according to the level of immunity (smallpox vaccine immunity or orthopoxvirus-related post disease immunity).

measurement of the level of population natural immunity and post vaccinal immunity to determine the Effective reproduction rate R and changes in R between 2000-2020 according to the evolution of immunity (smallpox vaccine immunity or orthopoxvirus-related post disease immunity).

Time frame: 36 months

measurement of the sensitivity and the specificity of the existing diagnostic tests and those developed within the framework of the project

sensitivity and specificity of the existing diagnostic tests and those developed within the framework of the project, as well as the reproducibility of measurements in relation to reference tests.

Time frame: 36 months

Identification and interpretation of genomic viral mutations from the viral sequences isolated from humans and animals in CAR for Phylogenetic and phylogeographic study of the monkeypox virus

identification and interpretation of mutations, search for the common ancestor.

Time frame: 36 months

Comparison of genetic proximities between different viral strains isolated in humans and animals in CAR and neighboring countries since 1980.

Data from ClinicalTrials.gov

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