Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men. And sleep disruption also remains a challenging problem in surgical settings. Postoperative sleep disturbances (POSD) are defined as changes in the sleep structure and quality of patients during the early stages after surgery, which are manifested as significantly shortened rapid eye movement (REM) sleep, prolonged awake time, and sleep fragmentation. Long-term POSD may increase the risk of postoperative delirium or cognitive dysfunction and delay recovery, thereby worsening the patient's physical condition. The aim of the study was to investigate the effect of sex differences on postoperative pain, inflammation, sleep quality and cognitive function among patients who have undergone video-assisted thoracoscopic surgery under general anesthesia.
Study Type
OBSERVATIONAL
Enrollment
100
patients receive Video-Assisted Thoracoscopic Surgery under general anesthesia
Shengjing Hospital
Shenyang, Liaoning, China
sleep quality of one night before surgery
use the athens insomnia scale to evaluate subjective sleep quality (0 to 24 points, with ≥ 6 points indicating a diagnosis of insomnia)
Time frame: one night before surgery
sleep quality of first night after surgery
use the athens insomnia scale to evaluate subjective sleep quality (0 to 24 points, with ≥ 6 points indicating a diagnosis of insomnia)
Time frame: first night after surgery
sleep quality of third night after surgery
use the athens insomnia scale to evaluate subjective sleep quality (0 to 24 points, with ≥ 6 points indicating a diagnosis of insomnia)
Time frame: third night after surgery
preoperative inflammation function
evaluate systemic immune inflammation index (SII) before operation
Time frame: three days before surgery
preoperative inflammation function
evaluate neutrophil / lymphocyte ratio (NLR)before operation
Time frame: three days before surgery
preoperative inflammation function
evaluate platelet / lymphocyte ratio (PLR) before operation
Time frame: three days before surgery
preoperative inflammation function
evaluate monocyte / lymphocyte ratio (MLR) before operation
Time frame: three days before surgery
postoperative inflammation function
evaluate systemic immune inflammation index (SII) after operation
Time frame: three days after surgery
postoperative inflammation function
evaluate neutrophil / lymphocyte ratio (NLR) after operation
Time frame: three days after surgery
postoperative inflammation function
evaluate platelet / lymphocyte ratio (PLR) after operation
Time frame: three days after surgery
postoperative inflammation function
evaluate monocyte / lymphocyte ratio (MLR) after operation
Time frame: three days after surgery
neuropsychological test
The neuropsychological test battery included the tests used to evaluate patients for delayed neurocognitive recovery in the International Study of Post-Operative Cognitive Dysfunction: (1) word learning: visual verbal learning test based on the Rey's auditory recall of words; (2) word recall: the number or words recalled from visual verbal learning trials after a 20-min delay; (3) cognitive flexibility: including trail making test A and B; (4) distractibility: Stroop color word interference test; and (5) working memory: letter-digit coding. If a patient exhibited delirium at a testing time, neuropsychological evaluation was postponed 3 days.
Time frame: Neuropsychological tests were carried out the day before and 5 to 7 days after surgery. The second neuropsychological test time for control subjects was 6 to 9 d
visual analog scale(VAS) score after surgery
evaluate VAS (0-10 points)score 24 hours after surgery
Time frame: 24 hours after surgery
postoperative adverse effects
evaluate postoperative adverse effect 24 hours after surgery
Time frame: 24 hours after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.