Low Intensity Aerobic Exercise and Active Exercises in Cancer Patients Receiving Palliative Care

Riphah International University22 enrolled

Overview

To compare the effect of low intensity aerobic exercise and active ROM exercises on cancer related fatigue and its associated symptoms and quality of life in cancer patients receiving palliative care.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Cancer

Interventions

Low Intensity Aerobic Exercises GroupOTHER

Intervention Low Intensity Aerobic Exercises i.e. stationary cycle(supervised) Intensity 55-65% of HRmax Frequency 3 times a week Duration 30 min each session

Active Exercises GroupOTHER

Intervention Upper and lower limb ROM \& stretching exercises Intensity As per tolerance Frequency 12 repetition/4sets per exercise 3 times/week Duration 30 minutes each session

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ability to give written consent. * Diagnosed advance cancer specifically gastrointestinal tract (GIT) cancer, Lung cancer and Breast cancer etc. (stage 2 and 3). * Intensity of fatigue ≥4 out of 10 on fatigue Numerical Rating Scale in first visit observation * Survival expectancy more than one month, * Functional status allowing the participants to participate in the proposed therapy. Exclusion Criteria: * Anemia (Hb ≤ 8g/dl), * Existence of other comorbidities causing fatigue (i.e. Parkinson's, Multiple sclerosis, Heart failure), * Infection requiring antibodies * bone metastases, * thrombocytopenia (\<50×109/l), * myocardial infarction within the past three months * uncontrolled hypertension (diastolic pressure \>95 mm Hg).

Locations (1)

Mubarak Hospital

Sargodha, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Fatigue Numeric Rating Scale

The fatigue numeric rating scale (NRS) is a single-item measure assessing severity of fatigue. We will use this in our study to measure the severity of cancer related fatigue in oncology patients receiving palliative care. The fatigue NRS is a patient- administered, single- item, 11- point horizontal scale anchored at 0 and 10, with 0 representing 'no fatigue' and 10 representing 'as bad as participant can imagine'. Changes from the baseline to 4 week

Time frame: 4th Week

Karnofsky Performance Status

The Karnofsky Performance Scale Index is an assessment tool for functional impairment. It can be used to compare effectiveness of different therapies and to assess the prognosis in individual patients. It is a standard way of measuring the ability of cancer patients to perform ordinary tasks. The Karnofsky Performance Status scores range from 0 to 100. A higher score means the patient is better able to carry out daily activities. Changes from the baseline to 4 week

Time frame: 4 Week

Edmonton Symptom Assessment Scale (ESAS)

This tool is designed to assess nine common symptoms experienced by cancer patients, including pain, tiredness, nausea, depression, anxiety, drowsiness, appetite, well-being, shortness of breath. The severity for each symptom ranges from 0 to 10 where 0 means absence of symptom to 10 being the worst possible severity. Changes from the baseline to 4 week

Time frame: 4 week

Brief Fatigue Inventory (BFI):

It is used to rapidly assess the severity and impact of cancer-related fatigue on daily functioning in past 24 hours, which requires a very short time to fill and the global fatigue scoring can be obtained by averaging all the 4 items on the BFI. Changes from the baseline to 4 week

Time frame: 4 week

Secondary Outcomes

Quality of life questionnaire for cancer patients treated with anti-cancer drugs (QOL-ACD):

Data from ClinicalTrials.gov

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