HIV-positive patients, women with a history of genital neoplasia and patients under pharmacologically immunosuppression (e.g. transplanted recipients, Crohn´s disease and Lupus) are a high-risk population for anal human-papillomavirus infection and associated complications, like anal precancerous lesions and anal squamous cell carcinoma. There is a lack of information on the prevalence of anal precancerous detected by routine colonoscopy in this population, by evaluating the squamocolumnar junction (the most susceptible area for lesions) during this procedure. Given, the increasing incidence rates of anal squamous cell carcinoma expected for the next two decades and the increase number of at-risk patients, the possible benefit of routine endoscopy in the diagnosis of anal precancerous lesions needs to be further explored.
Procedures in all patients: 1. Digital anorectal evaluation 2. Colonoscopy with retroflection and visualization of the anal squamocolumnar junction 3. After identification of this area 5% acetic acid will be applied. 4. Visualization under NBI/BLI. 5. Biopsies of all the suspected lesions of anal high-grade squamous lesions (HSIL).
Study Type
OBSERVATIONAL
Enrollment
100
Detection of anal HSIL in a routine colonoscopy by using acetic acid and NBI/BLI.
Fernando Pessoa Teaching Hospital
Gondomar, Porto District, Portugal
RECRUITINGPrevalence of anal high-grade squamous intraepithelial lesions in the squamocolumnar junction detected during routine colonoscopy.
Time frame: through study completion, an average of 3 years
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