Evaluation of antibody response against SARS-CoV-2 vaccination in patients treated with IO-treatment, in comparison with antibody titers in patients treated with non-IO treatment.
Blood samples will be analyzed to determine the magnitude of SARS-CoV-2 immunity in cancer patients treated with immunotherapy by quantifying antibodies and other tumor or blood-based biomarkers against SARS-CoV-2 epitopes following vaccination. We will also explore for potential development of autoantibodies and other blood-based biomarkers, following SARS-CoV-2 vaccination, and their correlation with clinical manifestation of IO related immune-related adverse events.
Study Type
OBSERVATIONAL
Enrollment
53
Princess Margaret Hospital
Toronto, Ontario, Canada
Concentration of SARS-CoV-2 antibodies
Time frame: 15 months
Number of immune-related adverse events
Time frame: 15 months
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