Analgesia Nociception Index（ANI）which is derived from heart rate variability can be used to detect noxious stimulation during propofol while changing remifentanil concentrations. The aim of this study is to verify the effectiveness of ANI predictability for actual surgical noxious stimuli while satisfying the individual analgesic status by pre-tetanus-induced ANI determination during sevoflurane while changing remifentanil concentrations.
General anesthesia with sevoflurane and remifentanil is widely used in minor surgeries. Monitoring noxious stimulation during general anesthesia is still worth further studies and reaching clinical consensus. Analgesia Nociception Index can be used to detect noxious stimulation during propofol while changing remifentanil concentrations. Previous studies suggest that an ANI≥50 can be useful in detecting sufficient analgesia for patients who cannot self-report pain. The aim of this study is to verify the effectiveness of ANI predictability for actual surgical noxious stimuli while satisfying the individual analgesic status by pre-tetanus-induced ANI determination during sevoflurane while changing remifentanil concentrations.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
32
For each participant, record the first concentration that ANI≥50 after the tetanic stimuli, as the sufficient concentration.
Infuse the sufficient concentration for at least 5min of the steady-state period, then surgical stimulus is applied. The surgical stimulus is defined as the first skin incision to establish pneumoperitoneum.
Beijing Chao Yang Hospital
Beijing, Beijing Municipality, China
To verify the effectiveness of ANI predictability for actual surgical noxious stimuli while satisfying the individual analgesic status by pre-tetanus-induced ANI determination.
Tetanic stimulations are applied at different effect site concentrations of remifentanil under sevoflurane anesthesia. ANI is range from 0-100. Bigger number means better analgesic level. ANI≥50 is considered to be under adequate analgesia. Tetanic stimulation is a standard tester of nociceptive stimulus. The number of ANI will fall down if the patient is feeling pain.
Time frame: Change from Baseline ANI that 2 minutes after applied tetanic stilumation
The ANI predictability for tetanic noxious stimuli
ANI is range from 0-100. Bigger number means better analgesic level. ANI≥50 is considered to be under adequate analgesia. The number of ANI will fall down if the patient is feeling pain.
Time frame: Change from Baseline Systolic Blood Pressure that 2 minutes after applied tetanic stilumation
The heart rate predictability for tetanic noxious stimuli
Heart Rate will go up if patient is feeling pain.
Time frame: Change from Baseline Heart Rate that 2 minutes after applied tetanic stilumation
The Bispectral Index predictability for tetanic noxious stimuli
Bispectral Index will go up if patient is feeling pain.
Time frame: Change from Baseline Bispectral Index that 2 minutes after applied tetanic stilumation
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