Denosumab and Screw Fixation for Osteoporotic Compression Fracture

Inclusion Criteria:• Must be age between 40 and 90 years old * X-ray diagnosis of 1-2 vertebral compression fractures * Dual energy X ray test bone mineral density T value less than -1 * fracture history lasted within 6 weeks * MRI showed bone marrow edema of injured segment * lower back pain, local spines tenderness Exclusion Criteria: * • Must be able to have no posterior vertebral wall fracture * Must be able to have no patients with intervertebral fissure * Must be able to have no infection * Must be able to have no malignancy * Must be able to have no neurological dysfunction * Must be able to have no previous use of anti-osteoporosis drugs within 6 weeks * Must be able to have no inability to perform magnetic resonance imaging * Must be able to have no prior back surgery * Must be able to have no other established contraindications for elective surgery