Serum Antimullerian Hormone Levels Among Epileptic Patients

Near East University, Turkey60 enrolled

Overview

The production of AMH starts in granulosa cells before birth and the levels within the serum decreases towards the menapouse. The levels of AMH do not change throughout the menstruation cycle hovewer, it can be affected in cases related to body mass index (BMI), polycyctic ovarian syndrome (PCOS). The lower levels of AMH had been documented after ovarian surgery, radiotheraphy and chemotheraphy. AMH is a member of Transforming Growth Faktor β (TGF- β ) and it has receptors in brain structures including hyppocammpus. It is highly active neurophysiologically and it has a protective effect against N-methyl-D -aspartate related neuronal injury that is demonstrated both in vivo and in vitro studies. As a result, being a neuroactive hormone; AMH may have an effect on seizures within epileptic patients or serum AMH levels may be effected in epileptic patients when compared with healthy ones.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Epilepsy Reproductive Issues

Interventions

serum antimullerian hormone will be analyzed for all participants

Eligibility

Sex: FEMALEMin age: 12 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy and epileptic volunteer females * Ages between 12-18 * After menarche Exclusion Criteria: * ovarian surgery, * history of radiotherapy * history of chemotherapy, * before menarche

Locations (1)

Near East University Faculty of Medicine

Nicosia, Cyprus

Outcomes

Primary Outcomes

serum anti-mullerian hormone levels

The comparison of serum levels of anti-mullerian hormone between epileptic and healthy groups

Time frame: baseline, at the time of examination

Data from ClinicalTrials.gov

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