The overarching aim of this study is to test the influence of daily consumption of a soluble corn fiber (SCF) known i.e., PROMITOR® Soluble Fibre™ for cognitive function among middle and older-aged adults.
Although regular consumption of soluble dietary fiber has been shown to support multiple markers of gastrointestinal and physical health, the effects of regular fiber consumption for promoting cognitive health remain unclear. Additionally, the GI microbiota-dependent mechanisms by which dietary fiber may impact markers of cognitive function remain understudied. Thus, the overarching aim of this study is to test the influence of daily consumption of a soluble corn fiber (SCF) known i.e., PROMITOR® Soluble Fibre™ for cognitive function among middle and older-aged adults. The primary hypothesis is that daily consumption of dietary fiber over a period of 4 weeks will significantly improve executive function. The secondary hypothesis is that the influence of SCF on cognitive outcomes will be mediated by improvement in GI bacterial taxa and fermentation-end product profiles. These hypotheses will be tested by conducting a 4 week randomized, double-blind, placebo-controlled cross-over study among healthy, i.e., free-living cognitively intact middle-aged and older adults between45-75 years of age. This work is significant because most Americans do not meet their recommended dietary fiber intake and there is a growing interest in understanding the potential benefits of consuming dietary fiber for broader health outcomes including both gastrointestinal and cognitive health.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
40
Participants will be asked to consume a packet of 22g Soluble Corn Fiber/day for 4 weeks
Participants will be asked to consume a packet of 22g Maltodextrin/day for 4 weeks
University of Illinois at Urbana-Champaign
Urbana, Illinois, United States
RECRUITINGAttention Accuracy
Behavioral performance measured as accuracy (%) during Flanker task
Time frame: 4 weeks
Attention Reaction Time
Behavioral performance measured as response time (ms) during Flanker task
Time frame: 4 weeks
P3 Amplitude
Amplitude (microvolt) of the P3 ERP waveform assessed during the Flanker task
Time frame: 4 weeks
Event-related potentials
Latency (ms) of the P3 ERP waveform assessed during the Flanker task
Time frame: 4 weeks
Relational Memory
Accuracy during a spatial reconstruction task
Time frame: 4 weeks
Gastrointestinal Microbiota
Taxonomic compositionprofiles of the gastrointestinal microbiota
Time frame: 4 weeks
Fecal Metabolites
Quantity of short-chain fatty acids in fecal samples
Time frame: 4 weeks
Mood/Well-being
Total score on surveys (POMS, PANAS, SF-36)
Time frame: 4 weeks
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