Study will examine the metabolic, physiological and cardiovascular changes by intake of New Zealand blackcurrant extract at rest and during moderate-intensity treadmill walking in healthy males.
The investigators will examine effects of acute intake, intermittent intake and chronic intake of New Zealand blackcurrant extract using indirect calorimetry and hemodynamic measurements.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
15
Capsules taken daily or intermittent
Mark Willems
Chichester, West Sussex, United Kingdom
Changes in heart rate from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Heart rate will be measured in beats/min.
Time frame: baseline, acute, one week and two weeks
Changes in stroke volume from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Stroke volume will be measured in mL.
Time frame: baseline, acute, one week and two weeks
Changes in cardiac output from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Cardiac output will be measured in L/min.
Time frame: baseline, acute, one week and two weeks
Changes in blood pressure from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
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The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Systolic, diastolic and mean arterial blood pressure will be measured in mmHg.
Time frame: baseline, acute, one week and two weeks
Changes in total peripheral resistance from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Total peripheral resistance will be measured in (mmHg·min)/L
Time frame: baseline, acute, one week and two weeks
Changes in oxygen consumption from baseline with acute intake, one week and two weeks intake.
The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Oxygen consumption will be measured in L/min
Time frame: baseline, acute, one week and two weeks
Changes in carbon dioxide production from baseline with acute intake, one week and two weeks intake.
The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Carbon dioxide production will be measured in L/min.
Time frame: baseline, acute, one week and two weeks
Changes in respiratory exchange ratio from baseline with acute intake, one week and two weeks intake.
The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Respiratory exchange ratio is unitless and calculated from the ratio of carbon dioxide production and oxygen consumption.
Time frame: baseline, acute, one week and two weeks
Changes in carbohydrate oxidation from baseline with acute intake, one week and two weeks intake.
The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Carbohydrate oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.
Time frame: baseline, acute, one week and two weeks
Changes in fat oxidation from baseline with acute intake, one week and two weeks intake.
The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Fat oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.
Time frame: baseline, acute, one week and two weeks