LIVER PAM A randomized, controled, open and unicentric trial comparing high (MAP 85-90 mmHg) and low (65-70 mmHg) target of mean arterial pressure in the first 24 hours after liver transplantation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
174
Targeting the weaning of vasopressors to a mean arterial pressure of 85-90mmHg in the first 24h after liver trasnplant.
Targeting the weaning of vasopressors to a mean arterial pressure of 65-70mmHg in the first 24h after liver trasnplant.
Hospital Das Clínicas Da Faculdade de Medicina Da Universidade de São Paulo
São Paulo, São Paulo, Brazil
incidence of Acute Kidney Disfunction
Incidence of acute kidney Disfunction according to kdigo criteria.
Time frame: 7 days
Mortality
percentage of mortality in 28 days
Time frame: 28 days
re-transplant
percentage of re-transplant in 28 days
Time frame: 28 days
Lenght of Hospitay Stay
LOS in 28 days
Time frame: 28 days
Lenght of ICU Stay
ICU LOS in 28 days
Time frame: 28 days
Days alive and out of hospital in 28 days
Number of days alive and out of hospital in 28 days
Time frame: 28 days
Substitutive Renal Therapy
percentage of TSR in 7 days
Time frame: 7 days
Days Alive and free of renal disfunction
Days Alive and free of renal disfunction in 28 days
Time frame: 28 days
Acute kidney insufficiency according to Urinary NGAL on d0 and D2
Percentage of renal disfunction according to NGAL criteria on D0 and D2
Time frame: 0d and 2d
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MAKE28
Major Kidney Events ( Death, persistent acute kidney disfunction or need of RRT in 28 days)
Time frame: 28 days
Liver graft primary disfunction ( Initial Poor Function)
percentage of Initial Poor Function in 7 days
Time frame: 7 days
Liver graft primary disfunction (primary nonfunction)
percentage of primary nonfunction in 10 days
Time frame: 10 days
Surgical site infection
percentage of SSI in 28 days
Time frame: 28 days
Need of Transfusion
percentage of Transfusion requirement in 7 days
Time frame: 7 days
Postoperative Major bleeding in 7 days
Bleeding that requires 2 units of blood transfusion in a single day or the need of a reoperation due to bleeding in the first 24 hours after surgery.
Time frame: 7 days
Incidence of Arrythmia requiring clinical treatment
percentage of Arrhythmia requiring treatment in 7 days
Time frame: 7 days