The Relationship Between Epicardial Fat Tissue and Cardiac Function in HFpEF Patients

Dongying Zhang1,083 enrolled

Overview

Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF\>50%), and ventricular muscle diastolic dysfunction and A clinical syndrome characterized by decreased compliance and increased stiffness. The pathogenesis of HFpEF is related to impaired lipid metabolism and inflammation. Epicardial adipose tissue (Epicardial Adipose tissue, EAT) is a kind of visceral adipose tissue, which is composed of adipose tissue deposited between the myocardium and the visceral layer of the pericardium. It is closely adjacent to the coronary arteries and myocardium. Related studies have shown that extracardiac Membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.However, there is still no research investigating the the relationship between epicardial fat thickness and Cardiac Function in HFpEF patients. This study intends to observe the relationship between epicardial fat thickness and left and right functions in patients with HFpEF, and evaluate whether epicardial fat thickness can be used as an indicator of left and right dysfunction.

Study Type

OBSERVATIONAL

Enrollment

1,083

Conditions

Heart Failure With Preserved Ejection Fraction

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult aged \>=18years old; * Diagnosed with HFpEF. Diagnostic criteria including: 1. left ventricular ejection fraction ≥50%； 2. with the symptoms and/or signs of heart failure； 3. BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL； 4. at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction Exclusion Criteria: * LVEF less than 45% at any time; * Severe liver failure; * Primary pulmonary hypertension; * Age \<18 years old.

Outcomes

Primary Outcomes

Epicardial Fat Tissue

Epicardial Fat Tissue by cardiac color Doppler ultrasound

Time frame: On admission

Cardiac Function

Left ventricular diastolic function and right ventricular systolic function by cardiac color Doppler ultrasound

Time frame: On admission

Composite Endpoint of Worsening Heart Failure Event and Cardiovascular Death

Time frame: From date of discharge until the date of first worsening HF event or date of death, whichever came first, assessed up to 5 years

Secondary Outcomes

Worsening HF Event

Worsening Heart Failure Event

Time frame: From date of discharge until the date of first worsening HF event or date of death, whichever came first, assessed up to 5 years

CV Death

Cardiovascular Death

Time frame: From date of discharge until the date of death, whichever came first, assessed up to 10 years

All-cause Death

Death from any causes