Study on the Etiology, Risk Factors and Pathogenesis of COPD Based on Clinical Bioinformatics

Inclusion Criteria: ① Inclusion criteria for patients with COPD: * Over 18 years of age. * FEV1 / FVC\< 70% was the diagnostic criterion for COPD after inhaling bronchodilators. ② Inclusion criteria for high-risk subjects: * Over 18 years of age. * Physical examination and routine laboratory tests were normal. * Chest CT to exclude other pulmonary diseases. * Lung function does not meet the diagnostic criteria for COPD. * having one of the following risk factors: A. Smoking: current smokers, smoking index (number of years of smoking × number of cigarettes per day)≥ L. B. Biofuel exposure: Subjects frequently use charcoal, wood, and animal dung for home heating and cooking Or crops are defined as having a history of exposure to biofuels. C. Dust and chemical exposure: mining, quarrying, casting, grain dust, paint, chemicals and others (including non-return) In the above categories of self-reported) occupational dust or gas smoke exposure for more than 1 year. ③ Inclusion criteria of healthy control subjects: * Over 18 years of age. * Physical examination and routine laboratory tests were normal. * Chest CT to exclude other pulmonary diseases. * Lung function does not meet the diagnostic criteria for COPD. * No risk factors (including smoking, biofuel exposure, dust or chemical exposure). Exclusion Criteria: * History of other chronic lung diseases, such as bronchiectasis, pulmonary interstitial fibrosis, etc. * History of acute lung disease within 3 months. * History of malignant tumor. * Pregnant and lactating women.