TransPERineal Fusion Biopsy Versus transrECTal

Inclusion Criteria: * Patient having had a multiparametric prostatic MRI with the realization of 3 sequences (T2, diffusion, perfusion) interpreted by a local referent radiologist in prostate MRI or whose PI-RADS score is confirmed by rereading by a local referent radiologist in prostate MRI in case prostate MRI performed outside the center; * Patient with at least one PI-RADS 4-5 lesion on MRI; * Patient eligible for prostate, transperineal and transrectal biopsies, targeted and systematized; * Patient with negative pre-biopsy antibacteriological urine examination ; * Patient with prostate specific antigen (PSA) level ≤ 20 ng / mL; * Patient capable of understanding the information related to the study, answering questionnaires in French, reading the instructions and having expressed their consent to participate in the study. Exclusion Criteria: * Patient who has already had a prostate biopsy; * Patient with stage ≥ cT3a prostate cancer according to TNM classification version 8 * Patient with negative MRI or whose lesions have a PI-RADS score \<4; * Patient with impassable rectal stenosis; * Patient with a dermatological disease preventing perineal access; * Patient with rectal amputation; * Patient presenting with a urinary tract infection; * Patient on anticoagulant treatment at an effective oral dose, not relayed; * Patient participating in another clinical trial, or in a period of exclusion from another clinical trial