Genetic Diagnosis and Human Growth Hormone Treatment in Small for Gestational Age Children With Short Stature

Inclusion Criteria: 1. Single birth, clinical diagnosis of SGA; 2. rhGH treatment beginned before puberty (Tanner stage I), regardless of gender; 3. Before starting rhGH treatment, height was lower than -2 SDS compared with normal children of the same age and sex; 4. All the subjects and their guardians signed the informed consent and the informed consent for genetic testing. Exclusion Criteria: 1. No efficacy and safety data were recorded after treatment with rhGH; 2. A history of blood transfusion within 3 months before the collection of the genetic blood samples, or a history of bone marrow transplantation between rhGH treatment and the enrollment in this study; 3. Other conditions that the investigator considered unsuitable for inclusion in this study.