Comparison of Microplastic Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women

Kutahya Health Sciences University40 enrolled

Overview

In this study, microplastic levels in the placenta and cord blood of pregnant women with fetal growth retardation and healthy pregnant women will be compared in placenta and cord blood samples after delivery.

The study will be conducted with a total of 40 pregnant women, 20 of whom are in the control groups and those with FGR diagnoses. Cases in both groups will be matched in terms of demographic information. Demographic information (including socioeconomic status, educational level, region of residence), ultrasound and Doppler examination results, newborn weight at birth, APGAR score, gender, mode of delivery, whether there is a need for neonatal intensive care or not will be recorded.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Microplastic Levels in Placenta and Cord Blood

Interventions

Analyzing of microplastic levelOTHER

Blood samples will be taken from the vein of the umbilical cord. Placental tissues will be taken from the maternal side of the placenta. Placental tissues and serum samples will be stored in the temperature set to -80 °C until analysis. Extraction methods involving chemical reactions will be used to separate and purify microplastics in placenta and cord blood samples. After the extraction process, analysis of microplastic levels in tissues and serum will be done by µ-Raman spectroscopy.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Between the ages of 18-40 years * Gestational age between 320/7 - 396/7 weeks * Singleton pregnancy * For the FGR group: estimated fetal weight \<10th percentile * For the control group: being healthy pregnant * Intact amniotic membrane Exclusion Criteria: \-

Outcomes

Primary Outcomes

Analyzing of microplastic levels in the placenta and cord blood of pregnant women

Microplastic levels in pregnant women's placenta and cord blood will be measured in placenta and cord blood samples after delivery.

Time frame: 1 year

Secondary Outcomes

Investigation of the effect of microplastic level in placenta and cord blood on FGR

If there is a significant difference in other data, including the microplastic level, in the FGR group, the effect of each factor on the development of FGR will be analyzed by multi logistic regression analysis. In addition, if the microplastic level is found to be significantly higher in the FGR group, the cut-off value will be obtained by ROC analysis.

Time frame: 1 month

Data from ClinicalTrials.gov

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