This study aims to evaluate the effects of erector spinae plane block on intraoperative fentanyl consumption in patients undergoing abdominal hysterectomy under general anesthesia. To our knowledge, no study in the literature demonstrates this effect.
This study will be performed in Fayoum University hospital after approval of the institutional ethics committee and written informed consent. This study will be conducted as a prospective, randomized, double-blind, parallel-group clinical trial. Inclusion criteria: * American Society of Anesthesiologists (ASA) physical status I, II patients who will be scheduled for elective abdominal hysterectomy. * Age range above 18. Exclusion criteria: * Patient refusal. * Significant renal, hepatic and cardiovascular diseases. * History of allergy to one of the study drugs. * Any contraindication to regional anesthesia such as local infection or bleeding disorders. * Chronic opioid use, history of chronic pain and cognitive disorders. The patients will be randomized into two groups: ESP block group who will receive preoperative US-guided bilateral ESP block with 20 ml of bupivacaine 0.25% on each side and Control group who will undergo the same procedure but with an injection of 20 ml of saline on a 1:1 ratio using a computer-generated random table. The patient's assigned group information will be elicited from a sealed opaque envelope by the anesthesiologist who will perform the ESP block and will not be involved in further data collection or patient care. The patients and both the surgical and anesthesia teams, who are responsible for patient care and data collection are blinded from the group assignments.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
100
ESP block group who will receive preoperative US-guided bilateral ESP block with 20 ml of bupivacaine 0.25% on each side
Fayoum University Hospital
Al Fayyum, Egypt
The total intraoperative fentanyl consumption (μg)
the total doses of intraoperative fentanyl consumption in (μg)
Time frame: operative time in hours
intraoperative sevoflurane consumption (ml)
intraoperative sevoflurane consumption (ml)
Time frame: operative time in hours
post-operative fentanyl consumption in (μg)
post-operative fentanyl consumption in the first 24 hours (μg)
Time frame: the first 24 hours postoperative
VAS score
visual analog score
Time frame: the first 24 hours postoperative
mean operative times (min)
operative times duration in (min)
Time frame: operative times in (min)
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