Topical Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Women Undergoing Elective Cesarean Section

Aswan University Hospital150 enrolled

Overview

In hypertensive women having an elective cesarean section, the effectiveness and safety of temporary uterine packing coupled with topical tranexamic acid as an adjuvant for decreasing blood loss during delivery were compared to placebo.

patients were allocated to one of two groups after induction of anesthesia. they received temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid or placebo

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

150

Conditions

Cesarean Section Complications

Interventions

Topical tranexamic acidDRUG

temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid

: normal salineOTHER

temporary uterine packing with gauze of the dimensions soaked with placebo to 2 gm tranexamic diluted in 60ml saline acid

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * hypertensive women undergoing elective cesarean section Exclusion Criteria: * Patients with cardiac, hepatic, renal, or thromboembolic disease. , * patients with the high possibility of the morbid adherent placenta, * known coagulopathy and * those presented with severe antepartum hemorrhage * refuse to participate

Outcomes

Primary Outcomes

intraoperative blood loss

measures the intraoperative blood loss by direct and gravimetric methods

Time frame: 30 minutes

Secondary Outcomes

need of blood transfusion

number of unites of blood transfusion

Time frame: 12 hours

need of uterotonic

misoprostol, oxytocin etc

Time frame: 24 hours

change in hemoglobin

Time frame: 24 hours

Data from ClinicalTrials.gov

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