Perioperative blockage of beta-adrenoreceptors is widely used in cardiac and non-cardiac surgery to reduce the rate of cardiovascular complications. Several randomized-controlled studies and meta-analysis showed that esmolol reduces the incidence of myocardial ischemia and arrhythmias in cardiac surgery as well as enhances postoperative cardiac performance. No studies assessed the influence of esmolol in patients with hypertrophic obstructive cardiomyopathy undergoing cardiac surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
80
E. Meshalkin National Medical Research Center
Novosibirsk, Russia
RECRUITINGPeak concentration of Troponin I
Time frame: From the randomization to the postoperative day 3 (POD 3)
The need for (yes/no) inotropic agents
Number of patients requiring inotropic support
Time frame: through study completion, an average of 4 weeks
The need for (yes/no) defibrillation
Number of patients requiring defibrlillation after removal of aortic cross clamp
Time frame: through study completion, an average of 4 weeks
The incidence of new-onset moderate and severe arrhythmias of cardiac arrest
Number of patients with arrhythmias
Time frame: through study completion, an average of 4 weeks
Left ventricular ejection fraction
Time frame: through study completion, an average of 4 weeks
Peak serum creatinine concentration
Time frame: through study completion, an average of 4 weeks
The incidence of acute kidney injury
Time frame: through study completion, an average of 4 weeks
Duration of mechanical ventilation
Time frame: through study completion, an average of 4 weeks
Duration of ICU stay
Time frame: through study completion, an average of 4 weeks
Duration of hospital stay
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Time frame: through study completion, an average of 4 weeks
30-day all-cause mortality
Time frame: through study completion, an average of 4 weeks
Presence of diastolic dysfunction
Time frame: through study completion, an average of 4 weeks
The dosage of inotropic agents (inotropic score)
Time frame: through study completion, an average of 4 weeks