St. John's Wort Photodynamic Therapy

Seoul National University Bundang Hospital31 enrolled

Overview

The investigators aimed to evaluated the efficacy and safety of SJW-PDT compared to indole-3-acetic acid (IAA)-PDT in the treatment of acne. The investigators also investigated the skin rejuvenating effects of SJW-PDT.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Acne

Interventions

PDTPROCEDURE

A 630 nm red light and a 520 nm green light of the light-emitting diode (LED) device (Nouvo-GB®) with an intensity of 35 mW⁄cm2 was simultaneously illuminated for 10 minutes (a total light dose of 21 J/cm2). Participants received a total of four treatments at 1-week intervals and were followed up 1 and 4 weeks after the last treatment.

Eligibility

Sex: ALLMin age: 25 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with mild to moderate facial acne * between 25 and 60 years old Exclusion Criteria: * history of oral retinoid treatment with the past 6 months * history of oral antibiotics, topical acne treatment, or skin rejuvenation treatment such as lasers and chemical peeling within the month before the start of the study

Locations (1)

Seoul National University Bundang Hospital

Seongnam, South Korea

Outcomes

Primary Outcomes

acne lesions

change in the number of acne lesions after the treatment

Time frame: 1 and 4 weeks after the last treatment

Secondary Outcomes

sebum secretion rate (μg/cm2)

Sebum secretion rate was measured with Sebumeter SM 815®.

Time frame: 1 and 4 weeks after the last treatment

Data from ClinicalTrials.gov

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