The present study is a double-blinded randomized clinical trial with a duration of 28 days.
The present study is a double-blinded randomized clinical trial with a duration of 28 days. 80 orally and systemically healthy participant will be allocated in the test (probiotic) and the control (placebo) group at baseline. The intervention is sugar stress, which will be applied at baseline and continue through day 14, followed by 14 days without sugar stress. Clinical measurements and sampling will be performed at baseline, day 14 and day 28 Primary endpoint: Changes in microbial composition. Secondary endpoints: Changes in clinical and immunological parameters
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
80
Sucrose rinsing for 14 days (8-10 times a day) followed by 14 days without sucrose rinsing
University of Copenhagen, Department of Odontology
Copenhagen, Denmark
Changes in microbial composition in dental plaque
Changes in alpha and beta diversity of microbial composition
Time frame: Baseline vs. Day 14 and Day 28
Changes in clinical parameters
Changes in levels of dental plaque and gingival inflammation
Time frame: Baseline vs. Day 14 and Day 28
Changes in salivary levels of inflammatory cytokines
Changes in mean salivary levels of selected inflammatory cytokines
Time frame: Baseline vs. Day 14 and Day 28
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