Absorption, Metabolism, and Excretion Study of [14C]-TNP-2092

Inclusion Criteria: 1. Capable of understanding the written informed consent form (ICF), willingly provide valid, signed written informed consent, and willing and able to comply with the schedule, requirements, and restrictions of the study 2. Males between 18 and 55 years of age (inclusive) at the time of Screening 3. Body mass index (BMI) ≥18.0 kg/m2 and ≤32.0 kg/m2 at Screening; body weight ≥55.0 kg and ≤100.0 kg at Screening 4. Considered to be in good health by the Investigator, as determined by medical history, physical examination, VS measurements, 12-lead ECG, and clinical laboratory test results 5. Male subjects with female sexual partner(s) of reproductive potential may be enrolled if the male: 1. is documented to be surgically sterile (i.e., successfully vasectomized), or 2. agrees to use 2 methods of highly effective contraception and agree to refrain from sperm donation from the time of Screening through 90 days post dose 6. Negative serology results for hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab), and human immunodeficiency virus antibody (HIV Ab) 7. Non-smoker (with no use of other tobacco or nicotine containing products, in any form), as documented by history (no nicotine within 6 months prior to Screening) and a negative cotinine test at Screening and Admission See Section 5.3 for details of nicotine and tobacco restrictions 8. Negative results for drugs of abuse and alcohol at Screening and Admission 9. Content of 14C in urine, whole blood, and/or plasma (per Investigator discretion) samples obtained at Screening does not significantly exceed the general environmental background 14C level At present, background level of 14C is 104 percent Modern Carbon (pMC). To be eligible for study enrollment, subjects must have ≤30 pMC in a plasma or urine sample analyzed with sodium benzoate carbon carrier or ≤150 pMC for a sample analyzed directly (with no carbon carrier). 10. Willing to comply with Pharmaron's COVID-19 policies. Exclusion Criteria: 1. Any contraindication to the use of rifampin/rifamycin or a fluoroquinolone 2. History or presence of any condition (e.g., chronic diarrhea) or prior surgery (e.g., gastric bypass) that, in the opinion of the Investigator, poses a significant risk to subject safety and/or achievement of study objectives 3. Clinically significant abnormal medical history, or any abnormal findings on physical examination, VS, ECG, or laboratory tests at Screening, Admission, or pre dose on Day 1 that, in the opinion of the Investigator, could jeopardize achieving the study objectives and/or compromise the subject's safety 4. History of cancer that has not been in full remission for \>5 years (except basal cell skin cancer or squamous cell skin cancer with history of curative treatment and no recurrence for \>1 year prior to Screening), as judged by the Investigator 5. Acute illness within 14 days prior to study drug administration on Day 1, unless mild in severity and enrollment is approved by both the Investigator and Sponsor's medical representative 6. COVID-19 positive for active disease 7. Any history of allergic drug reactions 8. History or presence of alcohol or drug abuse within 2 years prior to Screening 9. Recent history of incomplete bladder emptying with voiding or awakening more than once at night to void 10. Usual habit of \<1 or \>3 bowel movements per day 11. Exposure to radiation for therapeutic or diagnostic reasons (except dental X rays and plain X rays of thorax and bony skeleton) within the past 12 months prior to study drug administration on Day 1, or worker occupationally exposed to radiation 12. Participation in another clinical study in which a \[14C\] labeled drug was administered within 1 year prior to Admission 13. Administration of another investigational medication within 30 days (or 5 half lives, whichever is longer) prior to study drug administration 14. Participation in an investigational device study within 30 days prior to study drug administration 15. Any ECG abnormality considered to be clinically significant by the Investigator 16. QTcF interval (QT interval corrected for heart rate per Fridericia's formula) \>450 msec at Screening, Admission, or pre dose on Day 1 17. Family history of long QT syndrome or of unexplained sudden death in a first-degree relative under 50 years of age 18. Documented congenital or acquired long QT syndrome 19. Glomerular filtration rate (GFR) ≤80 mL/min/1.73 m2, as estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation 20. Presence of clinically significant hypertension, defined as systolic blood pressure (SBP) \>140 mmHg and/or diastolic blood pressure (DBP) \>90 mmHg, at Screening or Admission 21. Presence of clinically significant hypotension, defined as SBP \<90 mmHg and/or DBP \<50 mmHg, at Screening or Admission 22. Loss or donation of blood (approximately 500 mL) within 60 days prior to study drug administration on Day 1; donation of bone marrow or peripheral stem cells within 90 days prior to study drug administration on Day 1; or donation of plasma within 30 days prior to study drug administration on Day 1 23. Excessive consumption of alcohol, defined as \>3 alcoholic beverages per day (12 ounces of beer \[354 mL\], 5 ounces of wine \[148 mL\] or 1.5 ounce of distilled spirits \[44 mL\] is approximately equivalent to 1 alcoholic beverage) 24. Excessive consumption of coffee, tea, cola or other caffeinated beverages; excessive consumption is defined as \>6 servings per day (1 serving contains approximately 120 mg caffeine) 25. Venous access considered inadequate for PK sample collection; history or evidence of adverse symptoms associated with phlebotomy or blood donation 26. Employee or family member of the Investigator, study site personnel or Sponsor 27. Use/consumption of any medications or substances listed as prohibited 28. Any other reason that, in the opinion of the Investigator, would render the subject unsuitable for study enrollment.