Epidemiological Study in FRONtoTemporal Dementia

CENTOGENE GmbH Rostock2,287 enrolled

Overview

An international, multicenter, epidemiological observational study aims to investigate the prevalence of genetic etiologies in patients diagnosed with FTD or clinically suspected for FTD.

Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous neurodegenerative disease caused by the loss or damage of nerve cells in the brain's frontal and temporal lobes. This leads to abnormalities in behaviour, personality, and language comprehension problems. Also, people with FTD show movement disorders like tremor, rigidity, difficulty in coordination, muscle spasms and weakness. FTD's etiology is sporadic or heritable. Sixty to 70% of FTD cases are sporadic, while 30 to 40% are inherited (familial aggregation). For this study, blood samples were collected from clinically diagnosed or suspected FTD patients and were analysed for a broad range of pathogenic variants in genes associated with FTD. The scientific insights acquired from this study will help identify novel therapeutic targets and develop/ investigate potential disease-modifying drugs.

Study Type

OBSERVATIONAL

Enrollment

2,287

Conditions

Frontotemporal Dementia

Interventions

Genetic ScreeningDIAGNOSTIC_TEST

Blood samples will be collected from clinically diagnosed or suspected FTD patients and will be analysed for a broad range of pathogenic variants in genes associated with FTD.

Eligibility

Sex: ALLMin age: 25 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Informed consent, which includes reference to the genetic testing, is obtained from the participant/legal guardian * The participant is aged between 25 to 85 years * The participant is diagnosed with Frontotemporal dementia (FTD) or has signs or symptoms of FTD

Locations (37)

Outcomes

Primary Outcomes

To investigate the prevalence of genetic etiologies in FTD by genotyping FTD participants/ FTD suspected participants

Time frame: 15 months

Data from ClinicalTrials.gov

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AZ Damiaan

Ostend, West Flanders, Belgium

CHU de Liege

Liège, Belgium

Hanau Hospital

Hanau, Hesse, Germany

Gertrudis Klinik

Leun, Hesse, Germany

University Hospital Dresden

Dresden, Saxony, Germany

University Medical Center Hamburg Eppendorf

Hamburg, Schleswig-Holstein, Germany

University of Lübeck

Lübeck, Schleswig-Holstein, Germany

RWTH Aachen University

Aachen, Germany

Hochtaunus-Kliniken gGmbH

Bad Homburg, Germany

AGZ of Charite Universitätsmedizin Berlin

Berlin, Germany

...and 27 more locations