Efficacy of Letrozole Versus Clomiphene Citrate on Ovulation Induction in Patients With Polycystic Ovarian Syndrome

Nishtar Medical University78 enrolled

Overview

We aimed this study to determine and compare frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate as published literature shows variations.

Discrepancy between ovulation induction rate and pregnancy rate is related to anti-estrogenic effects on cervical mucus and endometrium and long acting gonadotrophins are more effective than clomiphene citrate. This study was aimed at comparing frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Polycystic Ovary Syndrome

Interventions

LetrozoleDRUG

Letrozole as 5mg from day 3 to 7 of menstrual cycle

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed cases of polycystic ovarian syndrome. Exclusion Criteria: * All women having endocrine disorders like thyroid disorders. * Women having hyperprolactinemia.

Locations (1)

Nishtar Medical University Hospital

Multan, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Induction of ovulation was assessed by Transvaginal scan (TVS)

Induction of ovulation was assessed by TVS. If follicle of \>2cm is found on 12 days TVS and smaller/collapsed on 16 days TVS, ovulation induction was labeled

Time frame: 12 to 16 days.

Data from ClinicalTrials.gov

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