Dysregulated Urea-synthesis at Terminal Uremia

University of Aarhus16 enrolled

Overview

This project will examine the dysregulation of the urea cycle in patients with terminal uremia using a validated method named "Functional Hepatic Nitrogen Clearance"

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Urea Cycle Disorder Uremia

Interventions

Aminoacid, alanine-infusionOTHER

During 3 hours, patient will receive alanine-infusion, while amino-acid and urea will be monitored by blood samples.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> or equal to 18 years * Chronic hemodialysis during 3 months * Patients with functioning arteriovenous-fistula assigned to "Center-Hemodialysis" at "Nyresygdomme, AUH Skejby" Exclusion Criteria: * Active infection * Conditions with vomiting or diarrhea * Diabetes * Active disease being treated with chemotherapy, radiationtherapy, biologic- or similar treatments. Disease under observation can be included. * Liver disease * Vessels on the upper extremities not suited for cannulation * Prednisolone treatment during the last 8 weeks * Pregnancy * BMI \> or equal to 30 or \< or equal to 18 * Physically or mentally condition that does not allow the project to be completed * Language-difficulties that does not allow the project to be completed

Locations (1)

University Hospital Aarhus

Aarhus N, Denmark

RECRUITING

Outcomes

Primary Outcomes

Urea synthesis rate during alanine infusion

Change in the synthesis of urea during a 3 hour period of alanine-infusion in pre and post hemodialysis patients. We will use a validated method named functional hepatic nitrogen clearance (FHNC) to evaluate the synthesis of urea. FHNC is calculated using the linear relation between urea nitrogen synthesis rate and blood-amino acid which is measured every hour. An estimated group of 10 dialysis patients will be included and compared to a clinical healthy group. The healthy group has also received alanine infusion and blood samples of urea and amino-acids has likewise been measured for every hour of infusion.

Time frame: 4 hours. 1 hour of blood sample measuring of baseline urea-synthesis rate and 3 hours of urea-synthesis rate during alanine-infusion

Central Contacts

Rasmus Eriksen, MD

CONTACT

30264691 rasmus.s.eriksen@hotmail.com

Data from ClinicalTrials.gov

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