Air Pollution and Health of COPD Patients

Peking University110 enrolled

Overview

This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.

This panel study was conducted in a group of stable patients with COPD in Beijing, China. The health measurements including lung function, blood pressure and airway inflammation were conducted, and morning urine, exhaled breath condensate, saliva and venous blood were collected at the time of enrollment and at 3, 6 and 9 months after enrollment. Individual exposures to fine particulate matter (PM2.5), black carbon (BC), ozone (O3) and nitrogen dioxide (NO2) were performed for 24 hours at each follow-up. And the daily concentrations of air pollutants were collected from the Beijing Air Quality Real-time Publishing Platform and meteorological data were collected from the National Meteorological Information Center. The linear mixed effects model was used to analyze the association between air pollution and cardiopulmonary health in patients with COPD.

Study Type

OBSERVATIONAL

Enrollment

110

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

Air pollutantsOTHER

Particulate matter and gaseous pollutants

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * doctor-diagnosed stable COPD patients * aged 40 to 80 years * lived in Beijing for over one year before being recruited * Agree to participate and sign the informed consent form. Exclusion Criteria: * Patients with a history of acute exacerbation in the last 1 month * Patients with other respiratory diseases such as bronchiectasis and asthma.

Locations (1)

Peking University

Beijing, China, China

Outcomes

Primary Outcomes

Lung function

Lung function test was conducted.

Time frame: Nine months

Secondary Outcomes

COPD Assessment Test scores

COPD Assessment Test (CAT) scores were used to assess quality of life in COPD patients on a scale of 0 to 40, with higher scores associated with poorer outcomes.

Time frame: Nine months

Modified British Medical Research Council (mMRC) Questionnaire score

Modified British Medical Research Council (mMRC) Questionnaire score was used to assess the severity of dyspnea on a scale of 0 to 4, with a higher score indicating a worse outcome.

Time frame: Nine months

ST. George's Respiratory Questionnaire scores

ST. George's Respiratory Questionnaire (SGRQ) scores were used to assess quality of life in patients with COPD on a scale of 0 to 100, with higher scores indicating poorer outcomes.

Time frame: Nine months

Blood pressure

Systolic and diastolic blood pressure of participants were measured at least three times by a trained technician.

Time frame: Nine months

Respiratory inflammation

Fractional exhaled nitric oxide (FeNO) test was conducted.

Time frame: Nine months

Airway and systemic oxidative stress levels

Exhaled Breath Condensate (EBC) and urine samples were collected for oxidative stress analysis.

Time frame: Nine months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.