Neoadjuvant Therapy With Proxalutamide Combined With Androgen Deprivation Therapy（ADT）for High Risk Prostate Cancer

Inclusion Criteria: 1. Patients must participate voluntarily and sign an informed consent form (ICF), indicating that they understand the purpose and required procedures of the study 2. Patients must be ≥ 18，male 3. Histopathological by Prostate biopsy confirmed prostatic cancer（No Neuroendocrine prostate cancer or small cell carcinoma） 4. High-risk prostate cancer (T2c≤ clinical stage ≤T4 or Gleason score ≥8 or PSA≥20ng/ml) 5. Patients willing to undergo laparoscopic radical resection of prostate cancer and extensive lymph node dissection 6. ECOG PS：0-1 Exclusion Criteria: 1. Imaging or biopsy confirmed distant Metastatic lesion 2. The number of regional lymph nodes metastasis \>3 3. Patients had undergone The treatment of Systemic chemotherapy and endocrine therapy for prostate cancer 4. Patients had undergone prostate surgery、radical radiotherapy or Bilateral orchidectomy