Direct Oral Anticoagulants for Prevention of lEft ventRIcular Thrombus After Anterior Acute Myocardial InFarction - APERITIF

Inclusion Criteria: * Age ≥ 18 years; * Anterior STEMI (e.g., ST elevation above the J-point of ≥0.1 millivolt in ≥two contiguous leads or left bundle branch block) or very high-risk NSTEMI (e.g., dynamic ECG changes or ongoing chest pain or acute heart failure or hemodynamic instability independent of ECG changes or life-threatening ventricular arrhythmias) with echographic evidence of anterior wall motion abnormalities and, with a culprit lesion of the proximal or mid portion of the left anterior descending (LAD) on the coronary angiography; * No contraindication to CMR (e.g., claustrophobia, pacemaker or defibrillator not compatible); * Ability to provide written informed consent and willing to participate in 1-month follow-up period. * Affiliation of social security regime. Exclusion Criteria: * Patients with cardiogenic shock (systolic blood pressure \<90 mmHg with clinical signs of low output or patients requiring inotropic agents); * Patients referred to surgery for coronary artery bypass grafting (CABG) or treatment of acute complications (e.g. ventricular septal rupture); * Patients treated with fibrinolytic therapy; * LV thrombus diagnosed before randomization using a transthoracic echocardiography; * Active major bleeding or major surgery within the last 30 days;High bleeding risk (patients considered at increased risk of bleeding during DAPT; e.g. PRECISE-DAPT score \>25; severe liver failure or Child Pugh class C); * Known history of intracranial hemorrhagic stroke or intra-cranial aneurysm; * Known history of peptic ulcer; * Known stroke (any type) within the last 30 days; * Known intolerance to aspirin, P2Y12 inhibitors, rivaroxaban and their excipients; * Patients with presence of malignant neoplasms at high risk of bleeding * Patients with hepatic impairment * According to the SmPC any contraindication to rivaroxaban, aspirin, clopidogrel, ticagrelor * Known intolerance to gadolinium chelates; * Chronic kidney disease (creatinine clearance (ClCr) \<30 mL/min); * Indication for anticoagulation (e.g. atrial fibrillation, mechanical valves, LV thrombus…); * Life expectancy \<1 month; * Known pregnancy at time of randomization (pregnancy test done) or breastfeeding women; * Currently participating in another trial * Protected adults (including individual under guardianship by court order) * Persons deprived of their liberty by judicial or administrative decision