Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Breast Cancer

Cancer therapy-related cardiac dysfunction (CTRCD)

Incidence of CTRCD defined as at least a 10% absolute change in LVEF by echocardiogram at follow-up relative to baseline to a value \< 50%

Time frame: through study completion (expected to be 15 years)

Symptomatic Heart Failure (HF)

Incidence of symptomatic heart failure (centrally adjudicated)

Time frame: through study completion (expected to be 15 years)

Change in Longitudinal Strain

Change in longitudinal strain by echo from baseline

Time frame: through study completion (expected to be 15 years)

Change in Circumferential Strain

Change in circumferential strain by echo from baseline

Time frame: through study completion (expected to be 15 years)

Change in Diastolic function

Change in diastolic function defined as E/e' by echo from baseline

Time frame: through study completion (expected to be 15 years)

Change in Left Ventricular (LV) Mass

Change in LV Mass by echo from baseline

Time frame: through study completion (expected to be 15 years)

Change in Relative LV Wall Thickness

Change in relative LV wall thickness from baseline

Time frame: through study completion (expected to be 15 years)

Change in Ventricular-Arterial Coupling

Change in Ventricular-Arterial Coupling defined as Ea/Ees by echo from baseline

Time frame: through study completion (expected to be 15 years)

Change in LV Twist

Change in LV Twist measured by 3D echo from baseline

Time frame: through study completion (expected to be 15 years)

Change in LV Torsion

Change in LV Torsion measured by 3D echo from baseline

Time frame: through study completion (expected to be 15 years)

Change in NTproBNP

Change in NTproBNP measured in batches from banked samples from baseline.

Time frame: through study completion (expected to be 15 years)

Change in high-sensitivity troponin (hsTnT)

Change in hs-TnT measured in batches from banked samples from baseline.

Time frame: through study completion (expected to be 15 years)

Change in patient reported fatigue

Change in Patient Reported Outcomes Information System (PROMIS) Fatigue Score from baseline. A higher score corresponds to higher reported levels of fatigue.

Time frame: through study completion (expected to be 15 years)

Change in patient reported quality of life

Change in Patient Reported Outcomes Information System (PROMIS) Global Health score from baseline. Higher scores indicate a healthier patient.

Time frame: through study completion (expected to be 15 years)

Change in patient reported activity level

Change in total weekly leisure activity in METS assessed by Godin Leisure Time Exercise Questionnaire from baseline.

Time frame: through study completion (expected to be 15 years)