Effects of Parenteral and Enteral Nutrition on Skeletal Muscle Genomics

Göteborg University39 enrolled

Overview

The study investigates effects related to muscle protein metabolism at provision of Parenteral or enteral nutrition

Randomized study investigation alterations in muscle protein metabolism at provision of parenteral or enteral (oral drink) nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis and protein degradation. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Muscle Loss

Interventions

Parenteral nutrition (PN)DIETARY_SUPPLEMENT

Overnight infusion of parenteral nutrition. Supplied as all-in-one-bag format. Infusion rate of 0.2 g N/kg/day.

Enteral nutritionDIETARY_SUPPLEMENT

Oral nutrition drink. 2 \* 200 ml on the night before operation. 1\* 200 ml on the morning of operation day.

ControlOTHER

Overnight infusion of crystalloid fluid (Ringer acetate) infused at the same rate (ml/kg) as intervention PN

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Major gastrointestinal surgery. * Assumed need of post-operative nutrition support. Exclusion Criteria: * Insulin dependent diabetes. * Steroid medication.

Locations (1)

Sahlgrenska University Hospital

Gothenburg, Region Västra Götaland, Sweden

Outcomes

Primary Outcomes

Muscle protein metabolism

Alterations in skeletal muscle gene expression quantified by microarray

Time frame: ~12-14 hours.

Data from ClinicalTrials.gov

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