fMRI Feasibility Older Hip Fracture Surgery

University of Nottingham10 enrolled

Overview

An assessment of the feasibility of structural and functional magnetic resonance imaging (MRI) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery

Postoperative delirium, an acute sate of confusion occurs with higher frequency in older people. Hip fracture surgery is a procedure associated with an increased risk of postoperative delirium. In the study the feasibility of achieving structure and functional connectivity imaging of the brain, using magnetic resonance imaging, in older people who are recovering from hip fracture surgery will be assessed. People who have recovered from post operative delirium and people who did not have postoperative delirium will be included.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Magnetic Resonance Imaging Hip Fractures Postoperative Delirium

Interventions

Functional MRIDIAGNOSTIC_TEST

Series of MRI scans of the brain

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria:Age * Age ≥ 65 years * Cognitively intact * primary admission for hip fracture surgery Exclusion Criteria: * Cognitive impairment * Less than moderate level of activities of daily living * History of neurosurgery/significant head trauma * Acutely unwell/moribund * Presence of neurological diseases including overt stroke, dementia, multiple sclerosis, Parkinson's disease, intracranial tumours and other significant neurologic disorders. * Postural or movement disorders likely to impede MRI scan * Contraindications to MRI * Complex fractures/multiple injuries

Outcomes

Primary Outcomes

Feasibility of MRI in older people following hip fracture surgery assessed by tolerability of transfer to scanner and the scanning process

The feasibility of transferring participants to and achieving structural and functional MRI scans. Specifically we will assess the number of participants in whom scans were successfully achieved

Time frame: From time of consent to day after MRI scan which is up to 5 days

Secondary Outcomes

Abnormalities of functional connectivity

Identify any differences in functional connectivity between the resolved delirium and the never delirium MRI scans

Time frame: Up to one month after scans have been achieved

Pain assessment.

An assessment of baseline pain levels and then repeat assessments of pain during transfer and the MRI scanning process using the numerical pain rating scale

Time frame: From immediately prior to transfer to the MRI suite until return to own hospital bed which is approximately 2 hours

Actual times taken to achieve scans

An assessment of unforeseen constraints on time taken to scan

Time frame: Up to 60 minutes

Participant feedback

The participant experience will be explored via verbal feedback which will be documented by the accompanying researcher

Time frame: Two occassions. The first immediately after return from the MRI scan suite. The second will occur the day after scanning. Each will take 5 minutes.

Central Contacts

Abiodun Moronke Noah, FRCA

CONTACT

01158231011 abi.noah@nottingham.ac.uk

Iain K Moppett, DM

CONTACT

01158230959 iain.moppett@nottingham.ac.uk

Data from ClinicalTrials.gov

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