Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease

Northwestern University42 enrolled

Overview

This study aims to determine whether changes in retinal vasculature seen on SS-OCTA can be correlated to degree of cardiovascular disease as measured by carotid duplex ultrasonography.

The study's primary objective is to determine whether measures taken from SS-OCTA, color fundus photography, and retinal exams can correlate with and predict the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography by examining the following parameters: retinal vessel caliber, retinal vessel density, retinal vessel perfusion, retinal vessel tortuosity, presence of Hollenhorst or other plaques, and/or areas of ischemia.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiovascular Diseases Retina; Change

Interventions

Swept Source Optical Coherence Tomography AngiographyDIAGNOSTIC_TEST

The PLEX Elite 9000 is an FDA cleared research device for use in ocular imaging obtained by Northwestern University by way of a purchase agreement with the manufacturer, Carl Zeiss Meditec, Inc. It is currently unavailable outside of participation in the ARI Network, a cloudbased storage and image processing platform using deidentified information shared between academic institutions. The ARI Network is managed by a group of physicians and scientists from around the world that are working to better understand eye diseases.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 95 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects between 18 and 95 years of age * Able to participate in a clinical eye examination setting * Able to consent * Subjects receiving standard of care carotid duplex ultrasounds Exclusion Criteria: * Inability to get high quality imaging for any reason (ex. Dense cataract, media opacity) * Lack of capacity to provide informed consent * Subjects younger than 18 years of age or older than 95 years of age * History of stroke or acute loss of vision * Unable to participate in a clinical eye examination setting

Locations (1)

Northwestern University/Northwestern Medical Group, Department of Ophthalmology

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Correlation with and prediction of the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography

Determining whether measures taken from SS-OCTA, color fundus photography, and retinal exams can correlate with and predict the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography by examining the following parameters: retinal vessel caliber, retinal vessel density, retinal vessel perfusion, retinal vessel tortuosity, presence of Hellenhorst or other plaques, and/or areas of ischemia.

Time frame: 2 hours

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.