Multicentre ObseRvational Study in Posterior mecHanical thrombEctomy: conscioUs Sedation vs General aneSthesia

Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta453 enrolled

Overview

The association of conscious sedation vs. general anesthesia in ischemic stroke with posterior circulation occlusions undergoing endovascular therapy, is istill unknown. No prospective or clinical trials have studied this effect on posterior circulation strokes. The choice of anesthetic regimen is ussually depending on local stroke-team protocols or neurointerventional preference. MORPHEUS Stroke Registry is a prospective multicentre observational study that investigates the association between anestheisa and functional outcome in patients with posterior circulation large vessel occlusion treated endovascularly.

Study Type

OBSERVATIONAL

Enrollment

453

Conditions

Mechanical Thrombectomy General Anesthesia Conscious Sedation Posterior Circulation

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subject aged ≥ 18 years * Evidence of posterior arterial occlussion (basilar artery, intracranial vertebral artery and posterior cerebral artery) * Patients eligible for mechanical thrombectomy Exclusion Criteria: * Patient's refusal to participate * Arterial recanalization prior to endovascular thrombectomy attempt * Patient unable to present or be available for follow-up

Outcomes

Primary Outcomes

Functional independence at 3 months

Rate of functional independence (modified Rankin Scale 0-2) at 3 months

Time frame: 3 months

Secondary Outcomes

First Pass Effect

Rate of complete successful recanalization (mTICI 2c-3) with one single pass of device

Time frame: 1 day

Mortality

Rate of mortality at 3 months

Time frame: 3 months

Successfull recanalization and complete recanalization according to endovascular technique

Rate of mTICI 3 and mTICI 2b-3 according to endovascular technique (contact aspiration, stentriever or combined)

Time frame: 1 day, revascularization grade will be assessed

Number of passes

Number of intracranial thrombectomy passes to achieve final reperfusion

Time frame: 1 day, number of device passes will be assessed

NIHSS at 24 hours

Rate of neurological status at 24 hours, dramatical neurological improvement after mechanical thrombectomy

Time frame: 24 hours

Type of anesthesic and outcome

Study of the type of anesthesic choice and complications, time of intubation and

Time frame: 3 months

Length of stentretriever and recanalization

Rates of FPE and succesful recanalization according to the length of stentretriever used

Time frame: 1 day, stentretriever type will be assessed

Arterial hypotension during anesthesic induction and outcome

Study of arterial hypotension during anesthesic induction and outcome

Time frame: 3 months

Bridging therapy and neurologial/functional outcomes

To study the association between bridging therapy and reperfussion rates, neurological status and funtional independence at 3 months.

Time frame: 1 day, type of previous fibrinolytic use will be assessed

Multicentre ObseRvational Study in Posterior mecHanical thrombEctomy: conscioUs Sedation vs General aneSthesia

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes