Covid-19 vaccines offered a good opportunity to counteract the spread of Sars-Cov-2 infection among the general population, reducing significantly both morbidity and mortality. Nevertheless, after the first and second doses of vaccination (regardless of the type of vaccine used) several women required gynaecological visits claiming menstrual Irregularities or abnormal uterine bleeding. Considering this anecdotal evidence, a questionnaire was designed to investigate systematically whether menstrual Irregularities or abnormal uterine bleeding occurred in a significant percentage of women undergoing first and second doses of covid-19 vaccination.
Study Type
OBSERVATIONAL
Enrollment
369
* First dose or complete cycle of Comirnaty (Pfizer/BioNTech) vaccine * First dose or complete cycle of Spikevax (Moderna) vaccine * First dose or complete cycle of AstraZeneca/Vaxzevria vaccine * Complete cycle of vaccination using one type of vaccine for the first dose and a different type for the second dose * Janssen (Johnson \& Johnson) vaccine (single dose)
University of Insubria
Varese, Italy
Frequency of the menstrual cycle
In women of reproductive age, any frequency shorter than 25 days or longer than 36 days will be defined as abnormal
Time frame: 30 days after the administration of the first and second doses of vaccine
Quantity of the menstrual cycle
In women of reproductive age, any quantity less than 30 ml or more than 80 ml will be defined as abnormal
Time frame: 30 days after the administration of the first and second doses of vaccine
Duration of the menstrual cycle
In women of reproductive age, any duration shorter than 3 days or longer than 7 days will be defined as abnormal
Time frame: 30 days after the administration of the first and second doses of vaccine
Post-menopausal bleeding
Any bleeding occurred in post-menopausal women
Time frame: 30 days after the administration of the first and second doses of vaccine
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