Toripalimab Combined With Concurrent Chemoradiotherapy in Cervical Cancer

Inclusion Criteria: * Age between 18 and 75; * Untreated patients with pathologically proven locally advanced cervical cancer; * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1 * Adequate hematological, renal and hepatic functions: 1. Hemoglobin \> 8.0 g/dl 2. Neutrophils \> 2000 cells/μl; Leukocytes \> 4 × 109/L 3. Platelets \> 100 × 109/L g. Serum urea nitrogen (BUN) ≤ 1.5 × upper normal limit (UNL) h. Serum creatinine (Cr) ≤ 1.5 × upper normal limit (UNL) d. Serum ALT/AST ≤ 2.5× UNL e. Serum Total bilirubin ≤ 1.5× UNL * Life expectancy \> 6 months * Eligible for concurrent chemoradiotherapy assessed by principle investigator; * No obvious active bleeding; * Written informed consent must be available before study registration Exclusion Criteria: * Recurrent or distant metastatic disease; * Prior malignancies (other than curable non-melanoma skin cancer) within 5 years; * Active autoimmune diseases requiring systemic treatment or other diseases requiring long-term use of substantial amount of hormones or other immunosuppressants; * Patients who need to receive systemic corticosteroids (dose equivalent to or higher than prednisone 10mg qd) or other immunosuppressants within 14 days before enrollment or during the study; * Vaccination of live attenuated vaccine 30 days before enrollment, or planned vaccination of live attenuated vaccine during the study; * Previous organ transplantation or HIV patients; * Allergic to macromolecular proteins /monoclonal antibodies, or to any test drug component; * Active acute or chronic viral hepatitis B or C. Hepatitis B virus (HBV) DNA\> 2000IU/ml or 104 copies/ml; hepatitis C virus (HCV) RNA\> 103 copies/ml.