Prospective Analysis Into Development of Hypernatremia in Critically Ill Patients

Catharina Ziekenhuis Eindhoven1,500 enrolled

Overview

Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and sodium balance or renal replacement therapy is lacking. The predecessor of this study was the HYPNIC trial which found that increased sodium load en decreased sodium excretion preceded hypernatremia development, but was lacking information on the first 48 hours, fluid balances were manually collected before a new data collection system was introduced and was suffering from substantial amounts of missing data and small population for trend analysis. This study aims to provide better insight in the development and recovery of hypernatremia while paying attention to the limitations from the HYPNIC trial.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Hypernatremia Critical Illness

Interventions

For every patient in ICU, a daily morning urine sample will be collected from the already collected urine via catheter.

Subanalysis for comparison of 24hour urine collection versus spot-check measurementsOTHER

For a subgroup of 30 sedated patients, 24 hour urine collection will be collected. In addition, every 2 hours a 10ml urine sample will be collected.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Admitted to Intensive Care Unit * Age 18 years or older Exclusion Criteria: * Age 17 years or younger

Locations (1)

Catharina Hospital Eindhoven

Eindhoven, North Brabant, Netherlands

Outcomes

Primary Outcomes

Hypernatremia

After one year of collecting data on fluid and sodium balances, the patients who developed hypernatremia during their admission in the Intensive Care Unit will be compared to the patients who remained normonatremic throughout their ICU admission.

Time frame: During admission in ICU

Secondary Outcomes

24 hour urine replacement for spot-checks

Assessing whether 24 hour urine collection can be replaced by spot-check measurements of urine by comparing both 24 hour urine and 2 hourly urine samples

Time frame: 24 hours

Central Contacts

Eveline Mestrom, MD

CONTACT

0031402399500 eveline.mestrom@catharinaziekenhuis.nl

Jonna van der Stam, MSc

CONTACT

0031402398675 Jonna.vd.stam@catharinaziekenhuis.nl

Data from ClinicalTrials.gov

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