cTBS is a promising novel intervention, which have strong potentials on moderating disease syndrome, suck as verbal hallucination, and cognitive deficits in schizophrenia, as it has been proved for the treatment of depression. Therefore, the investigators designed this randomized controlled clinical trial to evaluate the efficacy and safety of cTBS on prevention and treatment for cognitive deficiency, psychotic syndrome and metabolic side-effects in drug-naive first episode individual with schizophrenia.
cTBS is a promising novel intervention, which have strong potentials on moderating disease syndrome, suck as verbal hallucination, and cognitive deficits in schizophrenia, as it has been proved for the treatment of depression. Therefore, the investigators designed this randomized controlled clinical trial to evaluate the efficacy and safety of cTBS on prevention and treatment for cognitive deficiency, psychotic syndrome and metabolic side-effects in drug-naive first episode individual with schizophrenia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
44
transcranial magnetic stimulation with continuous theta burst pattern, 90% RMT, 50Hz within train and 5Hz train for 200 train and 40 second in total.
TMS coil vertical to the brain surface, with same protocol as cTBS
Central South University
Changsha, Hunan, China
Three-Factor Eating Questionnaire
min value 21, max value 84. The higher scores mean more unhealthy eating behavior.
Time frame: Change from Baseline to 6days and 36days
MCCB
The MATRICS™ Consensus Cognitive Battery
Time frame: Change from Baseline to 6days and 36days
The positive and negative syndrome scale
min score 30, max score 210. The higher score means more severe symptoms.
Time frame: Change from Baseline to 6days and 36days
BMI
body mass index
Time frame: Change from Baseline to 6days and 36days
Resting EEG
resting EEG (electroencephalogram) with eyes opened, eye closed and natural stimulation. The reEEG power spectra, functional connection will be calculated.
Time frame: Change from Baseline to 6days and 36days
fasting glucose
in mmol/l
Time frame: Change from Baseline to 6days and 36days
Triglyceride
in mmol/l
Time frame: Change from Baseline to 6days and 36days
Total Cholesterol
in mmol/l
Time frame: Change from Baseline to 6days and 36days
Low Density Lipoprotein
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in mmol/l
Time frame: Change from Baseline to 6days and 36days
High Density Lipoprotein
in mmol/l
Time frame: Change from Baseline to 6days and 36days