Oesophageal Pacing to Check Left Atrial Posterior Wall Isolation

University Hospital Plymouth NHS Trust52 enrolled

Overview

Patients undergoing hybrid AF ablation second stage catheter ablation have the posterior left atrium mapped to see it if is electrically isolated. This is done via a standard electrophysiogical study in accordance with routine clinical practice. Investigators propose to check left atrium posterior wall isolation via oesophageal pacing and compare this to findings from invasive study

Oesophageal temporary pacing of the heart is an established treatment in heart block and several catheters are licenced for this purpose with minimal procedural risks. Due to the position of the oesophagus, pacing from the oesophagus could sense and pace the posterior left atrium. If the posterior wall could be demonstrated to be electrically isolated with oesophageal pacing then invasive electrophysiological study such as the second stage of a hybrid AF ablation would be unnecessary. This would save patients from undergoing invasive left atrial mapping and exposure to the consequent risks of the procedure.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Persistent Atrial Fibrillation Atrial Fibrillation Ablation

Interventions

Oesophageal pacing after left atrial posterior wall isolationDEVICE

Following AF ablation with the aim of isolating the left atrial posterior wall oesophageal pacing and sensing is performed to check for left atrial posterior wall. entrance and exit block.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: • subjects capable of giving informed consent, * Male or female * Aged between 18 and 80 years * Undergoing ablation under general anaesthetic with planned isolation of the left atrial posterior wall or who have previously undergone either catheter or surgical ablation for AF with LA posterior wall isolation Exclusion Criteria: * Unable or willing to give fully informed written consent * Turned down for general anaesthetic * Pregnancy * Terminal illness * Any other significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate.

Locations (1)

Derriford Hospital

Plymouth, United Kingdom

Outcomes

Primary Outcomes

Left atrial posterior wall isolation

Measured via invasive left atrial mapping

Time frame: Through study completion, an average of 4 years

Secondary Outcomes

Complication rate

Documentation of the number of complications caused by the oesophageal pacing procedure

Time frame: Through study completion, an average of 4 years

Feasibility of using device

The success rate of left atrial posterior wall isolation.

Time frame: Through study completion, an average of 4 years

Data from ClinicalTrials.gov

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