Mobilization of Stem Cells With AMD3100 (Plerixafor) in Combination With G-CSF in Multiple Myeloma Patients

Inclusion Criteria: * Participants must be with biopsy-confirmed diagnosis of multiple myeloma before the first mobilization, in first or second complete or partial remission * The patient is eligible for autologous transplantation and treatment with an autologous peripheral Hematopoietic stem cell (HSC) transplant is planned * Eastern Cooperative Oncology Group performance status of 0 or 1 * Recovered from all acute toxic effects of prior chemotherapy or other cancer treatment * Has an actual body weight \<175% of their ideal body weight (IBW) * In agreement to use an approved form of contraception if of childbearing potential Exclusion Criteria: * If they had a comorbid condition which, in the view of the investigators, rendered the patient at high risk from treatment complications * Active brain metastases or myelomatous meningitis * Abnormal Electrocardiogram (ECG) with clinically significant rhythm disturbance (ventricular arrhythmias), or other conduction abnormality in the last year that in the opinion of the investigator warrants exclusion of the subject from the trial. * Active infection requiring antibiotic treatment * Fever (temperature \> 38°C) * Positive pregnancy test in female patients * Lactating females * Had prior autologous or allogeneic transplantation * Received bone-seeking radionuclides * Received \>6 cycles of induction therapy with lenalidomide * Received \>2 cycles of alkylating agent combinations * Received more than 2 regimens of alkylating agent combinations * Were less than 6 weeks off 1,3-bis(2-chloroethyl)-1- nitrosourea (BCNU) before first dose of G-CSF * Were less than 4 weeks off last cycle of chemotherapy before first dose of G-CSF * Failed previous hematopoietic stem cell collections or collection attempts * Received radiation therapy to more than or equal to 50% of the pelvis * Received specified treatment within specified duration. * Patients whose apheresis product were to be further selected and purified * Has received a live vaccine within 30 days of the planned start of study therapy. Seasonal flu vaccines that do not contain live virus are permitted * Had previously received experimental therapy within 4 weeks of enrolling or currently enrolled in another experimental protocol * White blood cell (WBC) count, Absolute neutrophil count (ANC)PLT count, estimated creatinine clearance, Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin should meet protocol requirements * Positive test for HIV, active Hepatitis B (HBV), or active Hepatitis C (HCV) within 30 days prior to the first dose of IMP * Has active central nervous system involvement * Individuals accommodated in an institution because of regulatory or legal order; prisoners or subjects who are legally institutionalized * Participant not suitable for participation, whatever the reason, as judged by the Investigator, including medical or clinical conditions, or participants potentially at risk of noncompliance to study procedures * Participants are dependent on the Sponsor or Investigator * Any specific situation during study implementation/course that may rise ethics considerations * Sensitivity to any of the study interventions, or components thereof, or drug or other allergy that, in the opinion of the Investigator, contraindicates participation in the study The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.