Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)

University of British Columbia18 enrolled

Overview

Salbutamol use is increased in areas with high levels of ozone pollution and the potential consequences of this are not well known. The purpose of this study is to examine the effect of salbutamol on lung function and inflammation in people with asthma and/or EIB exercising in ozone air pollution. To examine this, we are planning a randomized cross over trial where people with asthma and/or EIB complete sub maximal exercise in four conditions on four separate days. The four condition are: ozone + salbutamol, filtered air + salbutamol, ozone + placebo medication, and filtered air + placebo medication.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Asthma and/or Exercise Induced Bronchoconstriction Ozone Air Pollution

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Have asthma and/or EIB * Able to perform maximal exercise * Able to communicate sufficiently using the English language Exclusion Criteria: * Allergic to salbutamol (also known as Ventolin) * Pregnant or potentially pregnant * Have a history of smoking * Had an upper respiratory tract infection within the last 4 weeks * Have a chronic respiratory disease other than asthma or EIB

Outcomes

Primary Outcomes

Measured Before and 30 Minutes After Exercise in Each 1 Day Condition

Measure of pulmonary function

Time frame: Measured before and 30 minutes after exercise in each 1 day condition

Change in FVC From Baseline to 30 Minutes After Exercise