Effect of hetrombopag on the pharmacokinetics of rosuvastatin in healthy subjects.
The primary objective of the study is to evaluate the effect of hetrombopag on pharmacokinetics of healthy Chinese adult subjects after oral administration of rosuvastatin calcium tablets. The secondary objective of the study is to evaluate the safety of rosuvastatin alone and when co-administered with hetrombopag.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
14
Single oral dose of rosuvastatin on Day 1 or co-administered with hetrombopag on Day 11.
7.5 mg hetrombopag was administered on Day 6 to Day 11.
Xueying General Ding
Shanghai, Shanghai Municipality, China
Peak plasma concentration (Cmax)
Time frame: 0-72 hours post dose
Area Under the plasma concentration vs time curve (AUC0-72)
Time frame: 0-72 hours post dose
Area under the blood concentration vs time curve (AUC0-inf)
Time frame: 0-infinity
Other pharmacokinetics parameters of rosuvastatin
Tmax
Time frame: 0-72 hours post dose
The number of volunteers with adverse events as a measure of safety and tolerability
Time frame: up to Day 20
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.