The Role of Genetic Factors in the Development of Arterial Hypertension in the Kazakh Population

Asfendiyarov Kazakh National Medical University1,200 enrolled

Overview

This is a GWAS study that aims to identify possible candidate genes associate to arterial hypertension by exploring single nucleotide polymorphism (SNP) in a group of arterial hypertension, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with arterial hypertension

A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Study Type

OBSERVATIONAL

Enrollment

1,200

Conditions

Arterial Hypertension

Interventions

DNA analysisGENETIC

GWAS

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Persons with confirmed arterial hypertension; * The age of patients is from 18 to 55 years old inclusive; * Persons of Kazakh nationality, whose paternal and maternal grandparents identify themselves as Kazakhs; * Persons who are able and willing to provide written informed consent; * Persons capable and willing to comply with the research protocol; Exclusion Criteria: * Persons under 18 and over 55; * Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; * Pregnant or lactating women; * Tuberculosis of any localization in the active phase and in history; * Severe and decompensated diseases of the liver and kidneys, cardiovascular system; * Severe and decompensated course of endocrine diseases; * Autoimmune diseases; * Systemic diseases; * Cancer.

Locations (1)

Deputy head of Gerontology Center of Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan

Almaty, Kazakhstan

Outcomes

Primary Outcomes

number of SNPs associated with arterial hypertension

Using GWAS to identify candidate genes associate with arterial hypertension

Time frame: 1 year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.