The Role of Genetic Factors in the Development of Epilepsy in the Kazakh Population

Asfendiyarov Kazakh National Medical University600 enrolled

Overview

This is a GWAS study that aims to identify possible candidate genes associate to epilepsy by exploring single nucleotide polymorphism (SNP) in a group of epilepsy, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with epilepsy

A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies

Study Type

OBSERVATIONAL

Enrollment

600

Conditions

Epilepsy

Interventions

DNA analysisGENETIC

GWAS

Eligibility

Sex: ALLMin age: 0 YearsMax age: 5 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children with seizures, confirmed by EEG and no morphological damage to the brain, confirmed by MRI of the brain; * The age of the patients is from 0 to 5 years; * Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs; * Children are parents or legal guardians who have given written informed consent. Exclusion Criteria: * Children over 5 years old; * Children whose parents, according to the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; * Children with seizures with brain damage that cause epilepsy; * Children of a non-Kazakh ethnic group.

Locations (1)

Altynshash Jaxybayeva

Almaty, Kazakhstan

Outcomes

Primary Outcomes

number of SNPs associated with epilepsy

Using GWAS to identify candidate genes associate with epilepsy

Time frame: 1 year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.